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Research/研究

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2020年度

Ⅰ. 原著論文

  1. Keiko Bono, Chikako Hara-Miyauchi, Shunsuke Sumi, Hisayoshi Oka, Yasuyuki Iguchi, Hirotaka James Okano. Endosomal dysfunction in iPSC-derived neural cells from Parkinson’s disease patients with VPS35 D620N. Molecular Brain. 2020; 13:137.
  2. Kono Y, Terasawa Y, Sakai K, Iguchi Y, Nishiyama Y, Nito C, et al. Risk factors, etiology, and outcome of ischemic stroke in young adults: A Japanese multicenter prospective study. J Neurol Sci. 2020;417:11708.
  3. Murakami H, Shiraishi T, Umehara T, Omoto S, Takahashi M, Motegi H, Maku T, Nakada R, Sato T, Takatsu H, Komatsu T, Bono K, Sakai K, Mitsumura H, Iguchi Y. Differences in correlations of depression and anhedonia with cardiovascular sympathetic functions during a head-up tilt test in drug-naïve Parkinson’s disease patients. Neurological sciences 2020; 41:2825-2830.
  4. Oka H, Umehara T, Nakahara A, Matsuno H. Comparisons of cardiovascular dysautonomia and cognitive impairment between de novo Parkinson’s disease and de novo dementia with Lewy bodies. BMC Neurol.2020;20: 350.doi: 10.1186/s12883-020-01928-5.
  5. Omoto S, Murakami H, Shiraishi T, Bono K, Umehara T, Iguchi Y. Risk factors for minor hallucinations in Parkinson’s disease. Acta Neurol Scand. 2021;143:538-44.
  6. Sakai K, Komatsu T, Iguchi Y, Takao H, Ishibashi T, Murayama Y. Reliability of Smartphone for Diffusion-Weighted Imaging–Alberta Stroke Program Early Computed Tomography Scores in Acute Ischemic Stroke Patients: Diagnostic Test Accuracy Study. JMIR. 2020; 22(6): e15893
  7. Sakai, K, Sato, T, Komatsu, T, Mitsumura H, Iguchi Y, Ishibashi T, Murayama Y, Takeshita K, Takao H. Communication-type smartphone application can contribute to reducing elapsed time to reperfusion therapy. Neurol Sci (2021).
  8. Sakuta K, Yaguchi H, Sato T, Mukai T, Komatsu T, Sakai K, Mitsumura H, Okuno K, Tanaka T, Iguchi Y. The NAG scale can screen for hematoma expansion in acute intracerebral hemorrhage–a multi-institutional validation. J Neurol Sci. 2020 Jul 15;414:116834.
  9. Sakuta K, Sato T, Komatsu T, Sakai K, Mitsumura H, Matsushima S, Yaguchi H, Iguchi Y. The Impact of Cerebral Microbleeds Presence on Outcome Following Minor Stroke Treated with Antiplatelet Therapy. Front Neurol. 2020 Jun 16;11:522.
  10. Sato T, Sato S, Yamagami H, Komatsu T, Mizoguchi T, Yoshimoto T, Takagi M, Ihara M, Koga M, Iwata H, Matsushima M, Toyoda K, Iguchi Y. D-dimer level and outcome of minor ischemic stroke with large vessel occlusion. Journal of Neurological Sciences. 2020;413:116814.
  11. Sato T, Sakai K, Takatsu H, Tanabe M, Komatsu T, Sakuta K, Terasawa Y, Umehara T, Omoto S, Murakami H, Mitsumura H, Iguchi Y. Infarct site and prognosis in small subcortical infarction: Role of the corticospinal tract and lentiform. Journal of Neurological Science. 2020;418:117130.
  12. Shiraishi T, Nishikawa N, Mukai Y, Takahashi Y. High levodopa plasma concentration after oral administration predicts levodopa-induced dyskinesia in Parkinson’s disease. Parkinsonism Relat Disord. 2020;75:80-84.
  13. Shiraishi T, Sakai K, Mitsumura H, Arai A, Sato T, Komatsu T, Omoto S, Murakami H, Iguchi Y. Diagnostic yield of early examination for venous thrombosis in patients with cryptogenic stroke and a right-to-left shunt. Internal Medicine. 2020;59:1023-1028.
  14. Shiraishi T, Umehara T, Oka H, Nakahara A, Sato T, Matsuno H, Komatsu T, Omoto S, Murakami H, Iguchi Y.Clinical and neuroendocrinological characteristics of delayed orthostatic hypotension in Parkinson’s disease.Clin Auton Res. 2021 Jan 26. Online ahead of print.
  15. Suzuki M, Arai M, Hayashi A, Ogino M. Prescription pattern of anti-Parkinson’s disease drugs in Japan based on a nationwide medical claims database. eNeurologicalSci. 2020 Jul 16;20:100257. doi: 10.1016/j.ensci.2020.100257. eCollection 2020 Sep.
  16. Suzuki M, Arai M, Hayashi A, Ogino M. Adherence to treatment guideline recommendations for Parkinson’s disease in Japan: A longitudinal analysis of a nationwide medical claims database between 2008 and 2016. PLoS One. 2020 Apr 24;15(4).
  17. Umehara T, Oka H, Nakahara A, Shiraishi T, Sato T, Matsuno H, Komatsu T, Omoto S, Murakami H, Iguchi Y. Dopaminergic Correlates of Orthostatic Hypotension in de novo Parkinson’s Disease. J Parkinson Dis. 2020 Dec 20. doi: 10.3233/JPD-202239. Online ahead of print.
  18. Umehara T, Oka H, Nakahara A, Shiraishi T, Sato T, Matsuno H, Komatsu T, Omoto S, Murakami H, Iguchi Y. Sympathetic nervous activity and hemoglobin levels in de novo Parkinson’s disease. Clin Auton Res. 2020;30:273-78.
  19. Ando D, Yokota C, Koshino K, Yasuno F, Sato T, Yamamoto A, Odani H, Nakajima T, Higuchi T, Tatsumi E. Microstructural White Matter Changes Following Gait Training With Hybrid Assistive Limb Initiated Within 1 Week of Stroke Onset. Journal of Neurological Science. 2020;415:116939.
  20. Aoki J, Iguchi Y, Urabe T, Yamagami H, Todo K, Fujimoto S, Idomari K, Kaneko N, Iwanaga T, Terasaki T, Tanaka R, Yamamoto N, Tsujino A, Nomura K, Abe K, Uno M, Okada Y, Matsuoka H, Yamagata S, Yamamoto Y, Yonehara T, Inoue T, Yagita Y, Kimura K; ADS Investi. Cilostazol uncovers covert atrial fibrillation in non-cardioembolic stroke. J Neurol Sci. 2020;413:116796. doi: 10.1016/j.jns.2020.116796. Epub 2020 Mar 21.
  21. Aoki J, Iguchi Y, Urabe T, Yamagami H, Todo K, Fujimoto S, Idomari K, Kaneko N, Iwanaga T, Terasaki T, Tanaka R, Yamamoto N, Tsujino A, Nomura K, Abe K, Uno M, Okada Y, Matsuoka H, Yamagata S, Yamamoto Y, Yonehara T, Inoue T, Yagita Y, Kimura K; ADS Inves. Cilostazol addition to aspirin could not reduce the neurological deterioration in TOAST subtypes: ADS post-hoc analysis. J Stroke Cerebrovasc Dis. 2020 Dec 2;30(2):105494. doi: 10.1016/j.jstrokecerebrovasdis.2020.105494. Online ahead of print.
  22. Iijima M, Orimo S, Terashi H, Suzuki M, Hayashi A, Shimura H, Mitoma H, Kitagawa K, Okuma Y.Efficacy of istradefylline for gait disorders with freezing of gait in Parkinson’s disease: A single-arm, open-label, prospective, multicenter study. Expert Opin Pharmacother. 2019 Aug;20(11):1405-1411. doi: 10.1080/14656566.2019.1614167.
  23. Imai M, Tanaka M, Sakata M, Wagatsuma K, Tago T, Toyohara J, Sengoku R, Nishina Y, Kanemaru K, Ishibashi K, Murayama S, Ishii K: Metabolic Network Topology of Alzheimer’s Disease and Dementia with Lewy Bodies Generated Using Fluorodeoxyglucose Positron Emission Tomography. J Alzheimers Dis 2020, 73:197-207.
  24. Iritani, O, Okuno, T, Miwa, T, Makizako, H, Okutani, F, Kashibayashi, T, Suzuki, K, Hara, H, Mori, E, Omoto, S, Suzuki, H, Shibata, M, Adachi, H, Kondo, K, Umeda-Kameyama, Y, Kodera, K, Morimoto, S. Olfactory-cognitive index distinguishes involvement of frontal lobe shrinkage, as in sarcopenia from shrinkage of medial temporal areas, and global brain, as in Kihon Checklist frailty/dependence, in older adults with progression of normal cognition to Alzheimer’s disease. Geriatr Gerontol Int. 2021;21(3):291-298
  25. Miyazaki Y, Kazunori T, Iguchi Y, Hrano T, Metoki N, Tomoda M, Shiozawa M, Koge J, Okada Y, Terasawa Y, Kikuno M, Okano H, Hagi J, Nakajima M, Komatsu T, Yasaka M. Atrial fibrillation after ischemic stroke detected by chest strap style 7-day Holter monitoring and the risk predictors: EDUCATE-ESUS. J Atherosclero Thromb. 2020 Aug 15. doi: 10.5551/jat.58420. Online ahead of print.
  26. Okada K, Seki M, Yaguchi H, Sakuta K, Mukai T, Yamada S, Oki K, Nakahara J, Suzuki S. Polyradiculoneuropathy induced by immune checkpoint inhibitors: a case series and review of the literature. J Neurol. 2021; 268: 680-688.
  27. Takai Y, Misu T, Kaneko K, Chihara N, Narikawa K, Tsuchida S, Nishida H, Komori T, Seki M, Komatsu T, Nakamagoe K, Ikeda T, Yoshida M, Takahashi T, Ono H, Nishiyama S, Kuroda H, Nakashima I, Suzuki H, Bradl M, Lassmann H, Fujihara K, Aoki M. Myelin oligodendrocyte glycoprotein antibody-associated disease: an immunopathological study. Brain. 2020 Volume 143, Issue 5, May 2020, P 1431–1446.
  28. Tanei Z, Saito Y, Ito S, Matsubara T, Motoda A, Yamazaki M, Sakashita Y, Kawakami I, Ikemura M, Tanaka S, Sengoku R, Arai T, Murayama S: Lewy pathology of the esophagus correlates with the progression of Lewy body disease: a Japanese cohort study of autopsy cases. Acta Neuropathologica, 2020. 11.05 on line.
  29. Terasawa Y, Arai A, Sakai K, Mitsumura H, Iguchi Y. Optic disc protrusion on transocular ultrasonography is a new finding seen in patients with intracranial hypertension. Neurology and Clinical Neuroscience. 2020;8:47-49.

Ⅱ. 総説

  1. Sengoku R. Aging and Alzheimer’s disease pathology. Neuropathology 2020, 40(1): 22-29.
  2. Sengoku R. Neuropathological features of cognitive decline in Lewy body dementia. Neurol Clin Neurosci. 2020 Sep.
  3. 井口保之. 人を見極める. Medical Practice. 2020;37:1618.
  4. 井口保之,橋本洋一郎,岩間亨,小笠原邦昭,宮本享. 【肥満症総合戦略の新たな展開-神戸宣言2018に寄せて】日本脳卒中学会 日本脳卒中学会の取り組み. 肥満研究. 2020;26:292-293.
  5. 井口保之,岩間 亨,大木宏一,片岡大治,河野浩之, 山上宏,河村朗夫,福井重文,赤 禎治,金澤英明, 原英彦. 潜因性脳梗塞に対する経皮的卵円孔開存閉鎖術の手引き. 脳卒中. 2019;41:976-994.
  6. 大本周作. 嗅覚障害と認知症. 耳鼻咽喉科展望. 2020;63(4):182-6.
  7. 坂井健一郎,村上秀友. 瞳孔径・対光反射. ブレインナーシング:35(7)
  8. 作田健一,井口保之. 各論3:高血圧性脳出血の非手術治療. Clinical Neuroscience. 2020;38:614-615.
  9. 佐藤健朗,井口保之. 潜因性脳梗塞の診断と治療. Cardio-Coagulation. メデイカルビュー. 2020;7:202-206.
  10. 仙石錬平. 微小血管と認知症. 老年学・老年医学公開講座. 2020:19-27.
  11. 高津宏樹,三村秀毅,井口保之. 潜因性脳梗塞とは――潜因性脳梗塞の診断過程と経皮的卵円孔開存閉鎖術の適応評価. 医学のあゆみ. 2020;276:259-263
  12. 高橋潤一郎,三村秀毅,井口保之. 潜因性脳梗塞の抗血栓治療について. 循環器ジャーナル. 2020;68:680-686.
  13. 三村秀毅.カンパニオ2020 あなたの患者も脳卒中になるかもしれない! 院内発症急性期脳卒中を知ろう 早期に実施できる治療 院外ver(包括的脳卒中センターなど) 急性期治療ができない病院で発症した脳卒中.Brain Nursing 2020;36:115.
  14. 三村秀毅,井口保之脳梗塞(2020年改定版).今日の臨床サポート.東京:エルゼビア・ジャパン,2020:
  15. 谷口洋,宮川晋治,向井泰司.嚥下障害の診かた.脳血管障害などの緊急を要する嚥下障害,Parkinson病などの頻度の高い嚥下障害の鑑別ポイント.Medicina.2020;57: 2300-2302.
  16. 谷口洋.認知症における嚥下障害の診かた.老年精神医学雑誌.2020; 31: 1339-1344.
  17. 谷口洋,向井泰司,金沢英哲,山脇正永.私の治療方針.球症状を呈し,重症筋無力症と筋萎縮性側索硬化症の鑑別を要した76歳女性例.嚥下医学.2021;10: 53-61.
  18. 豊田一則,八木田佳樹,藤本茂,藤堂謙一,古賀政利,井口保之,河野浩之,田中寛大,猪原匡史,木村和美. 脳卒中を診る神経内科医を育てる. 臨床神経. 2020;60:735-742.
  19. 中根俊成溝口功一,阿部康二,熱田直樹,井口保之,池田佳生,梶龍兒,亀井聡,北川一夫,木村和美, 鈴木正彦,髙嶋博,寺山靖夫,西山和利,古谷博和, 松原悦朗, 村松慎一, 山村 修, 武田 篤, 伊東秀文. 日本神経学会災害対策委員会. 日本神経学会による災害対策:神経難病リエゾンの役割について. 臨床神経. 2020;60:643-652.

Ⅲ. 症例報告

  1. Kitagawa T, Sakuta K, Komatsu T, Aoki K, Sakai K, Ishibashi T, Mitsumura H, Murayama Y, Iguchi Y. Dramatical deformation of basilar artery dolichoectasia related to short-term recurrent stroke. Neurol Clin Neurosci. 2020; 00:1-3.
  2. Mitsumura H, Arai A, Sakai K, Terasawa Y, Kubota J, Iguchi Y. Outcomes of coil embolization for pulmonary arteriovenous fistula as evaluated using a novel soft ultrasound probe pasted to the neck. Intern Med. 2020; 59: 1883-1885.
  3. Onda A, Yamazaki M, Shimoyama T, Yaguchi H. Neuromyelitis optica spectrum disorder with deafness and an extensive brainstem lesion. Heliyon. 2021; 7: e06106.
  4. Sakuta K, Nakada R, Miyagawa S, Hasegawa I, Yaguchi H. Thrombolysis Following Central Venous Catheter Placement. J Stroke Cerebrovasc Dis. 2020 Nov;29(11):105267.
  5. Takatsu, H, Komatsu T, Fukasawa N, Fukuda T, Iguchi Y. Spontaneously changing MRI findings of primary central nervous system vasculitis: a case report. J Clin Neurosci. 2020 Nov 24;S0967-5868(20)31628-3. doi: 10.1016/j.jocn.2020.11.012. Online ahead of print.
  6. Ohara K, Sato T, Mitsumura H, Arai A, Komatsu T, Sakai K, Kawamura D, Ohashi H, Ishibashi T, Murayama Y, Iguchi Y. Ultrasound can detect alternating vertebral artery occlusions due to hangman fracture. Neurology and Clinical Neuroscience. 2020;8:196-188.
  7. 浅原有揮,余郷麻希子,宮川晋治,鈴木正彦.早期ステロイド・パルス治療により寛解に至り,後療法なしで1年間再発を認めなかったchronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS)の37歳男性例.臨床神経学.2020;60:682-687.
  8. 浅原有揮,向井泰司,須田真千子,鈴木正彦.スティック型嗅覚検査法にて経時的な嗅覚評価を行った非肺炎合併coronavirus disease 2019 (COVID-19)の53歳男性例.臨床神経学.2021;61: 140-143.
  9. 田邉真希,荒井あゆみ,中田遼志,佐藤健朗,小松鉄平,坂井健一郎,三村秀毅,井口保之.経頭蓋カラードプラ法による微小栓子検索が癌関連脳卒中の病態把握に有用であった1例.Neurosonology 33(3):80-82,2020
  10. 中田遼志,河野浩之,平野照之.経胸壁心エコーで僧帽弁に可動性構造物を認め,Libman-Sacks型心内膜炎と考えられたSLE合併脳梗塞例.Neurosonology 33(1):1-2, 2020
  11. 向井泰司,作田健一,宮川晋治,谷口洋.両側舌咽神経麻痺による嚥下障害で発症した急性骨髄性白血病の 1例.臨床神経学.2020;60:504-507
  12. 木澤 隆介,佐藤 健朗,梅原 淳,小松鉄平,大本周作,井口保之.DWI-FLAIRの比較が超急性期脳梗塞との鑑別に有用だったてんかん性発作の1例.臨床神経学.2021;61:166-171.

Ⅳ. 著書

  1. 井口保之. 頭蓋内圧亢進. 今日の診断指針第8版. 永井良三編著. 医学書院; 2020. P131-132.
  2. 大本周作. 脳脊髄液減少症. 今日の診断指針 第8版. 永井良三編著.東京: 医学書院; 2020. P133-5.
  3. 小松鉄平,井口保之. Ⅲ編 経頭蓋超音波 1章TC-CFI D右左シャント診断(椎骨動脈モニター法を含む)脳神経超音波マニュアル2020. 一般社団法人日本脳神経超音波学会; 2020. P 101-102.
  4. 仙石錬平. レビー小体型認知症.見てできる認知症ケアマネジメント図鑑.認知症ビジュアルガイド.鳥羽研二監修. 東京: 学研メディカル秀潤社; 2021. P45-50.

Ⅴ.その他

  1. Asahara Y, Miyagawa S, Suzuki M. Comparison of 123I-MIBG myocardial scintigraphy and 123I-FP-CIT SPECT between dementia with Lewy bodies and Parkinson’s disease. International congress of parkinson’s disease and movement disorders 2020. Virtual, September.
  2. Komatsu T, Ohta H, Takakura N, Kitagawa T, Hata J, Terawaki K, Koizumi M, Muta K, Kurashina Y, Onoe H, Okano H, Iguchi Y. A Novel Rat Model of Embolic Cerebral Ischemia Using a Cell-implantable Radiopaque Hydrogel Micro Fiber. International Stroke Conference. Online, 2021 March.
  3. Kono Y, Terasawa Y, Sakai K, Iguchi Y, Nishiyama Y, Nito C, et al. Investigation of living situations and risk factors for ischemic stroke in young adult; comparison to National Health and Nutrition Survey. The joint Europeans Stroke Organization and World Stroke Organization Conference 2020. Vienna (Virtual Conference), Nov.
  4. Mitsumura H, Kitagawa T, Tanabe M, Sato T, Takatsu H, Komatsu T, Sakuta K, Sakai K, Umehara T, Omoto S, Murakami H, Iguchi Y. How many cryptogenic stroke patients should be candidates for patent foramen ovale? International Stroke Conference 2021. A fully virtual experience, 2021 Mar.
  5. Murakami H, Shiraishi T, Umehara T, Omoto S, Takahashi M, MakuT, Motegi H, Sato T, Takatsu T, Komatsu T, Bono K, Sakai K, Mitsumura H, Iguchi Y. Pareidolia is associated with extrapyramidal symptoms in left side of the body in drug-naïve Parkinson’s disease patients. MDS Congress. Online, 2020 Sep.
  6. Sakai K, Iguchi Y, Suda S, Ueda M, Yagita Y, Kanzawa T, Okubo S, Ohara N, Mizunari T, Yamazaki M, Nakajima N, Kondo K, Fujimoto S, Inoue T, Iwanaga T, Terasawa Y, Shibazaki K, Kono Y, Nakajima M, Nakajima M, Mishina M, Adachi K, Imafuku I, Nomura K, Nagao T, Yaguchi H, Okamoto S, Osaki M, Kimura K ; PASTA investigators. Pre-stroke CHADS2 scores should be associated with onset severity and functional outcome in acute stroke patients with atrial fibrillation during oral anticoagulants – A sub-analysis of PASTA registry study -. International Stroke Conference. Online, 2021. March.
  7. Sakuta K, Yaguchi H, Nakada R, Sato T, Kitagawa T, Takatsu H, Miyagawa S, Komatsu T, Sakai K, Mitsumura H, Iguchi Y. Cerebral microbleeds load and long-term outcomes in minor ischemic stroke. International Stroke Conference 2021. Virtual, Mar.
  8. Sato T, Sakai K, Takatsu H, Tanabe M, Komatsu T, Sakuta K, Terasawa Y, Umehara T, Omoto S, Murakami H, Mitsumura H, Iguchi Y. Infarct Site and Prognosis in Small Subcortical Infarction: Role of the Corticospinal Tract and Lentiform. International Stroke Conference. Online, 2021. March.
  9. Takahashi J, Sakai K, Kitagawa T, Sato T, Takatsu H, Komatsu T, Mitsumura H, Murakami H, Iguchi Y. Serum arachidonic acid levels is a predictor of poor functional outcome in acute intracerebral hemorrhage. International Stroke Conference. Online, 2021. March.
  10. Umehara T, Oka H, Shiraishi T, Sato T, Nakahara A, Matsuno H, Komatsu T, Omoto S, Murakami H, Iguchi Y. Cardiac sympathetic dysfunction associated with dopaminergic depletion in striatal subregions in de novo Parkinson’s disease. 25th World Congress on Parkinson’s Disease and Related Disorders 2020, Abstract only.
最上部へ
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