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Research／研究

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業績

2021年度

Ⅰ. 原著論文

  1. Kitagawa T, Umehara T, Oka H, Shiraishi T, Sato T, Takatsu K, Nakahara A, Matsuno A, Bono K, Omoto S, Murakami H, Sengoku R, Iguchi Y. Association between heart rate variability and striatal dopamine depletion in Parkinson’s disease. J Neural Transm. 2021; 128:1835-1840.
  2. Komatsu T, Sakai K, Iguchi Y, Takao H, Ishibashi T, Murayama Y. Using a Smartphone Application for the Accurate and Rapid Diagnosis of Acute Anterior Intracranial Arterial Occlusion: Usability Study. J Med Internet Res. 2021; 23: e28192.
  3. Komatsu T, Ohta H, Motegi H, Hata J, Terawaki K, Koizumi M, Muta K, Okano HJ, Iguchi Y. A novel model of ischemia in rats with middle cerebral artery occlusion using a microcatheter and zirconia ball under fluoroscopy. Sci Rep. 2021; 11: 12806.
  4. Murakami H, Shiraishi T, Umehara T, Omoto S, Takahashi M, Motegi H, Maku T, Sato T, Takatsu H, Komatsu T, Bono K, Sakai K, Mitsumura H, Iguchi Y. Face pareidolia is associated with right striatal dysfunction in drug-naïve patients with Parkinson’s disease. Neurol Sci. 2021;42:5327-5334.
  5. Nakahara A, Sengoku R, Umehara T, Matsuno H, Yamazaki M, Oka H. Frontal lobe dysfunction is associated with reduced DAT-SPECT accumulation in Lewy body disease. J Neurol Sci. 2021;430:119998
  6. Oka H, Sengoku R, Nakahara A, Yamazaki M. Rasagiline does not exacerbate autonomic blood pressure dysreguraltion in early or mild Parkinson’s disease. Clin Park Relat Disord. 2021;Dec 13; 6:100124. doi: 10.1016/j.prdoa.2021.100124. eCollection 2022.
  7. Sakuta K, Yaguchi H, Nakada R, Sato T, Mukai T, Komatsu T, Sakai K, Mitsumura H, Iguchi Y. Cerebral Microbleeds Load and Long-Term Outcomes in Minor Ischemic Stroke J Stroke Cerebrovasc Dis. 2021;30:105973.
  8. Sakuta K, Yaguchi H, Nakada R, Mukai T, Miyagawa S, Okuno K, Fuga M, Iguchi Y. Validation of hyperacute stroke protocol modification aiming for time saving. Neurol Clin Neurosci. 2021;9:452-458.
  9. Sato T, Sakai K, Nakada R, Shiraishi T, Tanabe M, Komatsu T, Sakuta K, Terasawa Y, Umehara T, Omoto S, Mitsumura H, Murakami H, Matsushima M, Iguchi Y. Employment status prior to ischemic stroke and weekly variation of stroke onset. J Stroke Cerebrovasc Dis. 2021;30:105873.
  10. Takahashi J, Sakai K, Sato T, Takatsu H, Komatsu T, Mitsumura H, Murakami H, Iguchi Y. Serum arachidonic acid level is a predictor of poor functional outcome in acute intracerebral hemorrhage. Clin Biochem 2021:98:42-47.
  11. Aoki J, Iguchi Y, Urabe T, Yamagami H, Todo K, Fujimoto S, Idomari K, Kaneko N, Iwanaga T, Terasaki T, Tanaka R, Yamamoto N, Tsujino A, Nomura K, Abe K, Uno M, Okada Y, Matsuoka H, Yamagata S, Yamamoto Y, Yonehara T, Inoue T, Yagita Y, Ygita Y, Kimura K; ADS Inves. Microbleeds and clinical outcome in acute mild stroke patients treated with antiplatelet therapy: ADS post-hoc analysis. J. Clin. Neurosci. 2021;89;216-22.
  12. Inoue S, Igarashi A, Iguchi Y, Akagi T. Cost-Effectiveness Analysis of Percutaneous Patent Foramen Ovale Closure Preventing Secondary Ischemic Stroke in Japan. J Stroke Cerebrovasc Dis. 2021; 30 (8):105884. doi: 10.1016/j.jstrokecerebrovasdis.2021.
  13. Kumutpongpanich T, Ogasawara M, Ozaki A, Ishiura H, Tsuji S, Minami N, Hayashi S, Noguchi S, Iida A, Nishino I; OPDM_LRP12 Study Group, Mori-Yoshimura M, Oya Y, Ono K, Shimizu T, Kawata A, Shimohama S, Toyooka K, Endo K, Toru S, Sasaki O, Isahaya K, Takahashi MP, Iwasa K, Kira JI, Yamamoto T, Kawamoto M, Hamano T, Sugie K, Eura N, Shiota T, Koide M, Sekiya K, Kishi H, Hideyama T, Kawai S, Yanagimoto S, Sato H, Arahata H, Murayama S, Saito K, Hara H, Kanda T, Yaguchi H, Imai N, Kawagashira Y, Sanada M, Obara K, Kaido M, Furuta M, Kurashige T, Hara W, Kuzume D, Yamamoto M, Tsugawa J, Kishida H, Ishizuka N, Morimoto K, Tsuji Y, Tsuneyama A, Matsuno A, Sasaki R, Tamakoshi D, Abe E, Yamada S, Uzawa A. Clinicopathologic features of oculopharyngodistal myopathy with LRP12 CGG repeat expansions compared with other oculopharyngodistal myopathy subtypes. JAMA Neurol. 2021; 78: 853-863.
  14. Mok KY, East Asian Parkinson Diseasae Genomics Consortium (Sengoku R). The east Asian Parkinson disease genomics consortium. Lancet Neurol 2021;20:982.
  15. Ohta H, Komatsu T, Muta K, Koizumi M, Iguchi Y, Okano HJ. Marmoset Angiography just by percutaneous puncture of the caudal ventral artery. PLOS ONE. 2021;16:e0250576.
  16. Sakashita Y, Matsubara T, Tanaka T, Tanei Z, Motoda A, Yamazaki M, Kawakami I, Sengoku R, Saito Y, Arai T, Yamada M, Murayama S. Lewy pathology of the submandibular gland in Lewy body disease: A report of autopsy cases. Neruopathology 2021;41:476-483.
  17. Shigeta K, Suzuki K, Matsumaru Y, Takeuchi M, Morimoto M, Kanazawa R, Takayama Y, Kamiya Y, Okubo S, Hayakawa M, Ishii N, Koguchi Y, Ota T, Takigawa T, Inoue M, Naito H, Hirano H, Kato N, Ueda T, Akaji K, Iguchi Y, Miki K, Tsuruta W, Fujimoto S, Enomoto M, Aoyama J, Nakano T, Kimura K, SKIP study group. Intravenous Alteplase is Associated with First Pass Effect in Stent-retriever but not ADAPT Thrombectomy. Clin Neuroradiol. 2021; doi: 10.1007/s00062-021-01085-3.
  18. Suda S, Abe A, Iguchi Y, Yagita Y, Kanzawa T, Okubo S, Ohara N, Mizunari T, Yamazaki M, Nakajima N, Kondo K, Fujimoto S, Inoue T, Iwanaga T, Terasawa Y, Shibazaki K, Kono Y, Nakajima M, Nakajima M, Mishina M, Adachi K, Imafuku I, Nomura K, Nagao T, Yaguchi Y, Okamoto S, Osaki M, Kimura K. Characteristics of ischemic versus hemorrhagic stroke in patients receiving oral anticoagulants: Results of the PASTA study. Internal Medicine. 2021;doi: 10.2169/internalmedicine.8113-21.
  19. Suzuki K, Matsumaru Y, Takeuchi M, Morimoto M, Kanazawa R, Takayama Y, Kamiya Y, Shigeta K, Okubo S, Hayakawa M, Ishii N, Koguchi Y, Takigawa T, Inoue M, Naito H, Ota T, Hirano T, Kato N, Ueda T, Iguchi Y, Akaji K, Tsuruta W, Miki K, Fujimoto S, Higashida T, Iwasaki M, Aoki J, Nishiyama Y, Otsuka T, Kimura K, SKIP Study Investigators. Effect of mechanical thrombectomy without vs with intravenous thrombolysis on functional outcome among patients with acute ischemic stroke: the SKIP randomized clinical trial. JAMA.2021;325:244-253.
  20. Terao Y, Honma M, Asahara Y, Tokushige SI, Furubayashi T, Miyazaki T, Inomata-Terada S, Uchibori A, Miyagawa S, Ichikawa Y, Chiba A, Ugawa Y, Suzuki M. Time Distortion in Parkinsonism. Front Neurosci. 2021;15:648814. doi: 10.3389/fnins.2021.648814.
  21. 浅原有揮, 須田真千子, 鈴木正彦. Parkinson 病型進行性核上性麻痺とParkinson病における核医学画像の比較. 臨床放射線. 2021;66:1351-1356.
  22. 竹下康平，髙尾洋之, 坂井健一郎, 井口保之, 村山雄一. NDBサンプリングデータセットを利用した急性期脳梗塞の入院期間に関連する因子の研究. 脳卒中. 2021;43:306-12.

Ⅱ. 総説

  1. Asahara Y, Mukai T, Suda M, Suzuki M. Etiology and Treatment Approach for Visual Hallucinations in PD Dementia. Dementia in Parkinson’s Disease. IntechOpen. 2021.
  2. Murakami H, Ono K, Shiraishi T, Umehara T, Omoto S, Iguchi Y. Mini Review: Correlations of Cognitive Domains With Cerebrospinal Fluid α-Synuclein Levels in Patients With Parkinson’s Disease. Front Aging Neurosci. 2021;12:616357.
  3. Sengoku R. Great psychological distress induced by COVID-19 on healthcare workers in Japan. Intern Med. 2021;60: 2711-2712.
  4. 浅原有揮, 石橋賢士, 鈴木正彦. Parkinson 病の画像診断 (特集 Parkinson 病および類縁疾患の症候・診断). 脳神経内科. 2021;95:781-787.
  5. 三森雅広，三村秀毅，井口保之. ラクナ梗塞・分枝粥腫病(Branch atheromatous disease: BAD) 臨床医のための神経病理 再入門(56回). Clinical Neuroscience. 2021;39(12):1464-5.
  6. 三村秀毅．井口保之．超音波を用いた脳梗塞の治療．脳神経内科．2021; 95: 632-638.
  7. 三村秀毅．アテローム血栓性脳梗塞　画像診断．日本臨床増刊号．最新臨床脳卒中学（第二版）下．2021; 80： 146-150．
  8. 三村秀毅，井口保之．脳梗塞（2021年改定版）．今日の臨床サポート．東京：エルゼビア・ジャパン，2021:
  9. 茂木 晴彦，鈴木 重明．ニボルマブと副作用としての重症筋無力症，筋炎. Clinical Neuroscience．2021;39:1577-1579.
  10. 村上秀友. Parkinson病の認知機能障害と精神病症状. 難病と在宅ケア. 2021;27:10-14.
  11. 奥村元博，三村秀毅，井口保之. 急性期脳梗塞の薬物療法：非心原性脳梗塞（ラクナ梗塞，アテローム血栓性脳梗塞） 月間薬事. 2021;63(16):1-46.
  12. 坂井健一郎, ミンガッチーニ徴候. ブレインナーシング:2021夏季増刊号
  13. 作田健一，井口保之. 【内科疾患の診断基準・病型分類・重症度】(第7章)神経・筋　脳血管障害.内科. 2021;127(4):812-7.
  14. 仙石錬平. 嗅覚・味覚障害のサイエンス：今日的意義. パーキンソン病，アルツハイマー病における嗅覚障害. 自律神経 2021;58（４）:294-297.
  15. 仙石錬平.【動的ヘテラルキー-脳は階層固定的か？】各論　ヘテラルキーからみた神経疾患と治療　嗅球とパーキンソン病. Clinical Neuroscience 2021; 39: 878-882.
  16. 仙石錬平. パーキンソン病講座　パーキンソン病の進展. 難病と在宅ケア 2021; 27: 32-35.
  17. 仙石錬平.【パーキンソン病を解剖する-過去，現在，そして未来へ】パーキンソン病の病理　過去，現在，未来. 医学のあゆみ 2021; 278: 821-826.
  18. 仙石錬平.【嗅覚・味覚障害】Parkinson病とAlzheimer病の嗅覚障害. 脳神経内科 2021; 95: 510-514.
  19. 仙石錬平.【Parkinson病および類縁疾患の症候・診断】Parkinson病におけるLewy病理と臨床症候. 脳神経内科 2021; 95: 741-748.
  20. 鈴木正彦．日常診療におけるSPECTの臨床応用とその解釈．神経治療．2021；38：73-78.
  21. 高津宏樹, 三村秀毅, 井口保之. 潜因性脳梗塞の診断過程と経皮的卵円孔開存閉鎖術の適応評価.　医学のあゆみ. 2021;276:259-263.
  22. 高津宏樹, 小松鉄平, 山根禎一, 井口保之. 医原性心房中隔欠損による右左シャント.　Neurosonology. 2021;34:80-82.
  23. 谷口洋，坂本剛，鈴木重明．免疫チェックポイント阻害薬による神経系免疫関連有害事象．神経治療．2021；38:661-665.

Ⅲ. 症例報告

  1. Kitagawa T, Komatsu T, Omoto S, Sato T, Takatsu H, Sakai K, Umehara T, Murakami H, Mitsumura H, Iguchi Y. A case of idiopathic hypertrophic pachymeningitis with high adenosine deaminase in cerebrospinal fluid. Clin Neurol Neurosurg. 2021;211:107056.
  2. Kurihara S, Sato T, Murakami H, Komatsu T, Sakai K, Umehara T, Omoto S, Mitsumura H, Iguchi Y. Crossed Choreoathetosis Caused by Unilateral Thalamic Hemorrhage. J Stroke Cerebrovasc Dis．2021: 106049．
  3. Takahashi J, Komatsu T, Sakai K, Iguchi Y. Pseudo-porencephaly Mimicking Multiple Intracerebral Hemorrhages. Intern Med 2021:60:4009-4010.
  4. Takahashi J, Umehara T, Mitsumura H, Murakami H, Iguchi Y. Hyperadrenergic Orthostatic Hypotension With Pure Peripheral Sympathetic Denervation Associated Wirh Sjogren’s Syndrome. Cureus 2021:13:e17805.
  5. Takatsu H, Komatsu T, Fukasawa N, Fukuda T, Iguchi Y. Spontaneously changing MRI fingdings of primary central nervous system vasculitis: A case report. J Clin Neurosci. 2021;83:125-127.
  6. Hatano S, Kanzaki G, Marumoto H, Niikura T, Honda K, Nakada Y, Morita M, Hasegawa T, Yokoo T. Near-sudden unexpected death in a patient with epilepsy undergoing hemodialysis. CEN Case Reports. 2021;10: 582-587.

Ⅳ. 著書

  1. 井口保之. 高血圧性脳症. 今日の治療指診2021年版. 高木誠編著. 東京: 医学書院; 2021. P957.
  2. 井口保之. 脳血管障害. 薬が見える（第二版） Vol.1. 東京: Medic Media; 2021. P202−23.

Ⅴ. 研究費

  1. 三村秀毅．頸部貼付型超音波によるPFOを伴う潜因性脳梗塞の診断とPFO閉鎖術の効果判定．基盤研究(C)．令和2年度〜令和5年度
  2. 坊野恵子．レトロマーを標的としたパーキンソン病治療戦略．若手研究．平成３０年度〜令和3年度
  3. 小松鉄平．細胞含有ハイドロゲルファイバーによる血管内治療．上原記念生命科学財団研究奨励金．令和3年度
  4. 村上秀友．内因性ドパミンの賦活によるパーキンソン病の治療効果を予測する神経心理学的背景. 基盤研究(C)．令和3年度〜令和7年度
  5. 白石朋敬．オートファジー障害に着目したパーキンソン病 東京慈恵会医科 モデルiPS細胞の解析　特別研究員奨励費　令和4年〜5年度

Ⅵ. その他

  1. Iguchi Y, Ueno Y. Topics PFO closure in Japan. The 2021 Annual Meeting of Taiwan Stroke Society 2021. Taipei, November
  2. Komatsu T, Hada T, Kida H, Takahashi J, Maku T, Nakada R, Kitagawa T, Sato T, Takatsu H, Sakuta K, Sakai K, Umehara T, Murakami H, Mitsumura H, Abo M, Iguchi Y. Safety and effects of high-frequency rTMS in acute intracranial hemorrhage patients. International Stroke Conference 2022. New Orleans, Feb.
  3. Mitsumura H, Nakada R, Kitagawa T, Tanabe M, Sato T, Takatsu H, Komatsu T, Sakuta K, Sakai K, Umehara T, Murakami H, Iguchi Y. Diagnostic utility of transcranial color flow imaging identifying high risk patent foramen ovale. International Stroke Conference 2022. Hybrid, 2022 Feb.
  4. Okumura M, Sato T, Takatsu H, Komatsu T, Sakuta K, Sakai K, Umehara T, Mitsumura H, Murakami H, Iguchi Y. Periventricular Hyperintensity on Magnetic Resonance Imaging Predicts Unfavorable Outcomes After Intracerebral Hemorrhage.International Stroke Conference 2022. online, March.
  5. Sakuta K, Yaguchi H, Nakada R, Sato T, Kitagawa T, Takatsu H, Miyagawa S, Komatsu T, Sakai K, Mitsumura H, Iguchi Y. Cerebral microbleeds load and long-term outcomes in minor ischemic stroke. International Stroke Conference 2021. Virtual, Mar.
  6. Takahashi J, Sakai K, Kitagawa T, Sato T, Takatsu H, Komatsu T, Umehara T, Mitsumura H, Murakami H, Iguchi Y. The novel predictors of poor functional outcome in acute lacunar infarction by using hierarchical cluster analysis of clinical variables. International Stroke Conference 2022. New Orleans+Virtual, February.
  7. Takakura N, Ohta H, Komatsu T, Kurashina Y, Okano HJ, Onoe H. Catheter delivery of radiopaque cell-encapsulated hydrogel microfibers for cell therapy. the 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2021. California, Oct
  8. Kitagawa T, Umehara T, Shiraishi T, Sato T, Takatsu H, Komatsu T, Sakai K, Omoto S, Murakami H, Mitsumura H, Oka H, Iguchi H. The relation between striatal neurodegeneration and heart rate variability in Parkinson’s disease. 第62回日本神経学会学術大会．WEB開催，5月．
  9. Komatsu T，Takahashi J, Shiraishi T, Kitagawa T, Sato T, Takatsu H, Sakai K, Umehara T, Omoto S, Murakami H, Mitsumura H, Iguchi Y. Urinary Immunoglobulin is Independently Associated with Deep and Infratentorial Cerebral Microbleeds. 第62回日本神経学会学術大会．京都, 5月.
  10. Sato T, Sakai K, Komatsu T, Takahashi J, Shiraishi T, Kitagawa T, Tanabe M, Takatsu H, Sakuta K, Umehara T, Omoto S, Murakami H, Mitsumura H, Iguchi Y. Low dihomo-γ-linolenic acid is associated with an unfavorable outcome in cardioembolism. 62nd Annual Meeting of the Japanese Society of Neurology 2021. Kyoto, May
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東京慈恵会医科大学 内科学講座 脳神経内科

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