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Research／研究

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業績

2024年度

Ⅰ. 原著論文

  1. Akagi T, Hara H, Kanazawa H, Fukui S, Hashimoto Y, Iguchi Y, Iwama T, Kataoka H, Kawamura A,Kawano H, Oki K, Yamagami H, Investigators the PJP. Real-World Patent Foramen Ovale (PFO) Closurein Japan ―30-Day Clinical Outcomes From the AmplatzerTM PFO Occluder Japan Post-Marketing Surveillance Study―. Circ J. 2024; 88(9): 1391-7.
  2. Okazaki S, Yamamoto H, Asakura K, Omae K, Maeda H, Tanaka K, Yamamoto S, Hirano T, Iguchi Y, Sakaguchi M, Koga M, Ihara M, Toyoda K, Noguchi T, Sakai N, Yamagami H. Optimal antithrombotic therapy in ischemic stroke patients with non-valvular atrial fibrillation and atherothrombosis: study protocol for a randomized controlled trial. Front Neurol. 2024; 15: 1468523.
  3. Oyama N, Oki K, Nakajima M, Matsumoto K, Omori T, Hayase M, Ohta T, Koga M, Koyama T, Fujimoto S, Iguchi Y, Kakuda W, Ogasawara K, Rehabilitation PT for the E and S of AS. Impact of the COVID-19 Pandemic on Acute Stroke Rehabilitation in Japanese Primary Stroke Centers: A Nationwide Cross-Sectional Study Using a Web-Based Questionnaire Survey. Eur Neurol. 2024; 87(4): 169-76.
  4. Aoki J, Suzuki K, Sakamoto Y, Matsumaru Y, Takeuchi M, Morimoto M, Kanazawa R, Takayama Y, Kamiya Y, Shigeta K, Okubo S, Hayakawa M, Ishii N, Koguchi Y, Takigawa T, Inoue M, Naito H, Ota T, Hirano T, Kato N, Ueda T, Iguchi Y, Akaji K, Tsuruta W, Miki K, Fujimoto S, Higashida T, Iwasaki M, Kanamaru T, Saito T, Katano T, Kutsuna A, Nishiyama Y, Otsuka T, Kimura K, Investigators S study. High plasma BNP concentration associates with clinical outcome after mechanical thrombectomy: Post hoc analysis of SKIP. J Stroke Cerebrovasc Dis. 2024; 33(11): 107943.
  5. Suda S, Iguchi Y, Yagita Y, Kanzawa T, Okubo S, Fujimoto S, Kono Y, Kimura K, Investigators on behalf of P. High brain natriuretic peptide level is associated with severe stroke in patients taking oral anticoagulants: A sub-analysis of the PASTA registry study. J Neurol Sci. 2024; 458: 122935.
  6. Toyoda K, Kusano K, Iguchi Y, Ikeda T, Morishima I, Tomita H, Asano T, Yamane T, Nakahara I, Watanabe E, Koyama J, Kato R, Morita H, Hirano T, Soejima K, Owada S, Abe H, Yasaka M, Nakamura T, Kasner S, Natale A, Beinart S, Amin AN, Pouliot E, Franco N, Hidaka K, Okumura K. Global Results of Implantable Loop Recorder for Detection of Atrial Fibrillation After Stroke: Reveal LINQ Registry. J Am Hear Assoc. 2024; 13(21): e035956.
  7. Nishiyama Y, Miyamoto S, Sakaguchi M, Sakai N, Yoshida K, Tokuda N, Ichi S, Iguchi Y, Koga M, Yamaura I, Hirano T, Yamagami H, Kimura K. Clinical characteristics of stroke in SARS-CoV-2 infected patients in Japan: A prospective nationwide study. J Neurol Sci. 2024; 457: 122865.
  8. Nakajima M, Oki K, Omori T, Koyama T, Oyama N, Koga M, Hayase M, Ohta T, Matsumoto K, Iguchi Y, Fujimoto S, Kakuda W, Ogasawara K, Rehabilitation PT for the E and S of AS. A nationwide survey for the provision of acute stroke rehabilitation in Japan: initial dose and weekend/holiday rehabilitation. J Stroke Cerebrovasc Dis. 2024; 33(2): 107550.
  9. Sengoku R, Arakawa A, Matsubara T, Kameyama M, Tokumaru AM, Ishii K, Kanemaru K, Tarutani A, Hasegawa M, Iwata A, Murayama S, Saito Y. Argyrophilic Grain Disease Clinically Presenting as Progressive Supranuclear Palsy with Progressive Gait Freezing. Mov Disord Clin Pract 2025 in print.
  10. Hatano T, Sengoku R, Nagayama H, Yanagisawa N, Yoritaka A, Suzuki K, Nishikawa N, Mukai Y, Nomura K, Yoshida N, Seki M, Matsukawa MK, Terashi H, Kimura K, Tashiro J, Hirano S, Murakami H, Joki H, Uchiyama T, Shimura H, Ogaki K, Fukae J, Tsuboi Y, Takahashi K, Yamamoto T, Kaida K, Ihara R, Kanemaru K, Kano O. Impact of Istradefylline on Levodopa Dose Escalation in Parkinson’s Disease: ISTRA ADJUST PD Study, a Multicenter, Open-Label, Randomized, Parallel-Group Controlled Study. Neurol Ther 2024; 13(2): 323-8.
  11. Matsubara T, Ishii K, Saito Y, Tokumaru AM, Arakawa A, Hara M, Kurihara M, Sengoku R, Kanemaru K, Iwata A, Arai T, Miyashita A, Ikeuchi T, Hasegawa M, Murayama S, Saito Y. Neurofibrillary tanglepredominant dementia followed by amyloid β pathology: a clinico-radio-pathological case providing insights into current disease-modifying therapeutic strategy. Acta Neuropathol Commun 2024; 12(1): 98.
  12. Arakawa A, Goto R, Higashihara M, Hiroyoshi Y, Shioya A, Hara M, Orita M, Matsubara T, Sengoku R, Kameyama M, Tokumaru AM, Hasegawa M, Toda T, Iwata A, Murayama S, Saito Y. Clinicopathological study of dementia with grains presenting with parkinsonism compared with a typical case. Neuropathology 2024; 44(5): 376-87.
  13. Arakawa A, Murayama S, Morimoto S, Matsubara T, Sengoku R, Kameyama M, Tokumaru AM, Tarutani A, Hasegawa M, Iwata A, Toda T, Saito Y. A case of argyrophilic grain disease with an initial clinical diagnosis of Parkinson’s disease. J Neurol 2024; 271(12): 7628-32.
  14. 大本周作，木之下節夫，増田圭司．労働者における心理，身体的要因による認知機能低下の検知における認知機能チェックツールの有用性の検討．労働安全衛生研究2024; 17(2): 127-32.
  15. Umehara T, Mimori M, Kokubu T, Ozawa M, Shiraishi T, Sato T, Onda A, Matsuno H, Omoto S, Murakami H, Oka H, Iguchi Y. Serum phosphorus levels associated with nigrostriatal dopaminergic deficits in drug-naïve Parkinson’s disease. J Neurol Sci. 2024; 464: 123165.
  16. Umehara T, Mimori M, Kokubu T, Ozawa M, Shiraishi T, Sato T, Onda A, Matsuno H, Omoto S, Sengoku R, Murakami H, Oka H, Iguchi Y. Peripheral immune profile in drug-naïve dementia with Lewy bodies. J Neurol. 2024; 271(7): 4146-57.
  17. Umehara T, Mimori M, Kokubu T, Ozawa M, Shiraishi T, Onda A, Matsuno H, Omoto S, Murakami H, Iguchi Y. Enhanced visual illusions in Parkinson’s disease with neurogenic orthostatic hypotension. 2024;
  18. Sakai K, Suda S, Iguchi Y, Abe A, Yagita Y, Kanzawa T, Okubo S, Fujimoto S, Kimura K. High pre-stroke CHADS2 score predicts unfavorable functional outcome in acute cardioembolic stroke patients prescribed oral anticoagulant therapy: A sub-analysis of the PASTA registry study. J Stroke Cerebrovasc Dis. 2024; 33(2): 107519.
  19. Sakuta K, Imahori T, Molaie A, Ghovvati M, Rao N, Tateshima S, Kaneko N. Water content for clot composition prediction in acute ischemic stroke. PLoS One. 2024 May 24; 19(5): e0304520.
  20. 岡本圭史，黒川雅史，國枝顕二郎，大野友久，金沢英哲，宮川晋治，重松孝，藤島一郎．体幹側屈位と頸部回旋位を組み合わせた頬杖嚥下により咽頭通過が改善した3症例．嚥下医学2025; 14(1): 75-80.
  21. Komatsu T, Okumura M, Kida H, Takahashi J, Maku T, Kitagawa T, Sato T, Takatsu H, Sakuta K, Sakai K, Umehara T, Mitsumura H, Oseto H, Iguchi Y. Thin aortic arch plaque is associated with the development of atrial fibrillation for embolic stroke of undetermined source in patients with an insertable cardiac monitor. Int J Cardiol. 2024; 399: 131769.
  22. Komatsu T, Ohta H, Takeda M, Matsumura Y, Yokoyama M, Wang Z, Okano HJ, Iguchi Y. Novel Rat Model of Embolic Cerebral Ischemia Using a Radiopaque Blood Clot and a Microcatheter Under Fluoroscopy. Transl Stroke Res. 2024; 1-9.
  23. Komatsu T, Hada T, Sasaki N, Kida H, Maku T, Nakada R, Kitagawa T, Sato T, Takatsu H, Sakuta K, Sakai K, Umehara T, Mitsumura H, Abo M, Iguchi Y. Effects and safety of high-frequency rTMS in subacute ischemic stroke patients. J Neurol Sci. 2024; 462: 123069.
  24. Komatsu T, Motegi H, Mimori M, Okumura M, Masui M, Kida H, Ozawa M, Matsuno H, Sakuta K, Bono K, Sakai K, Mitsumura H, Iguchi Y. Predictors of achieving minimal manifestations or better status in ocular myasthenia gravis with immunotherapy. J Neurol. 2025; 272: 243.
  25. Takahashi K, Hamada Y, Kobayashi M, Kobayashi S, Kanbayashi T, Hatanaka Y, Nakayama T, Imafuku I, Matsuno H, Iguchi Y, Katada F, Fukutake T, Ando T, Mikata T, Usui T, Uchino K, Nishiyama K, Sonoo M. Utility of the Repetitive Nerve Stimulation Test and Needle EMG in the Trapezius Muscle for the Early Diagnosis of ALS. J Clin Neuromuscul Dis. 2024; 26(1): 1-11.
  26. Kitagawa T, Mitsumura H, Sato T, Takatsu H, Komatsu T, Sakuta K, Sakai K, Iguchi Y. Relation between severity of cerebral small vessel disease and pulsatility index of internal carotid artery in small vessel occlusion. Clin Neurol Neurosurg. 2024; 237: 108127.
  27. Kitagawa T, Sengoku R, Ozawa M, Matsuno H, Umehara T, Nakahara A, Oka H. Association between sebum secretion and cardiac sympathetic dysfunction in Parkinson’s disease． Parkinsonism and Related Disorders 2024; 129: 107178．
  28. Nakada R, Sakuta K, Sato T, Okumura M, Kida H, Yamamoto S, Takahashi J, Kitagawa T, Takatsu H, Miyagawa S, Komatsu T, Sakai K, Mitsumura H, Yaguchi H, Iguchi Y. Intracranial atherosclerotic disease mechanism indicates poor outcomes of thrombectomy in acute cerebral infarction with large vessel occlusion: A matched cohort study. J Neurol Sci. 2024; 466: 123235.
  29. Shiraishi T, Bono K, Hiraki H, Manome Y, Oka H, Iguchi Y, Okano HJ. The impact of VPS35 D620N mutation on alternative autophagy and its reversal by estrogen in Parkinson’s disease. Cell Mol Life Sci. 2024; 81(1): 103.
  30. Motegi H, Kufukihara K, Kitagawa S, Sekiguchi K, Hata J, Fujiwara H, Jinzaki M, Okano H, Nakamura M, Iguchi Y, Nakahara J. Non-lesional white matter changes depicted by q-space diffusional MRI correlate with clinical disabilities in multiple sclerosis. J Neurol Sci. 2024; 456: 122851.
  31. Ozawa M, Shiraishi T, Murakami H, Yoshimaru D, Onda A, Matsuno H, Komatsu T, Sakuta K, Sakai K, Umehara T, Mitsumura H, Okano HJ, Iguchi Y. Structural MRI study of Pareidolia and Visual Hallucinations in Drug-Naïve Parkinson’s disease. Sci Rep. 2024; 14(1): 31293.
  32. Ozawa M, Murakami H, Muraoka Y, Ibukuro M, Shiraishi T, Onda A, Matsuno H, Bono K, Umehara T, Omoto S, Okano HJ, Iguchi Y. Putamen dopaminergic dysfunction is associated with sleep disturbance in drug-naïve patients with Parkinson’s disease. Sleep Med. 2025 Feb 21; 129: 82-88.
  33. Ozawa M, Murakami H, Shiraishi T, Matsuno H, Bono K, Umehara T, Omoto S, Sengoku R, Shimizu H, Sarukawa H, Okumura M, Masui M, Kida H, Motegi H, Komatsu T, Sakuta K, Sakai K, Mitsumura H, Okano HJ, Iguchi Y. Sleep disturbance is associated with worsening quality of life in patients with multiple system atrophy. Clin Neurol Neurosurg. 2025 March; 250: 108794.
  34. Mimori M, Katsumoto A, Okamoto T, Sato W, Lin Y, Yamamura T, Takahashi Y. Ofatumumab for multiple sclerosis with disability accumulation. J Neurol Sci. 2025 Jan 15; 468: 123356.
  35. Masui M, Sato T, Okumura M, Ishikawa T, Sakuta K, Kokubu T, Takahashi J, Kitagawa T, Tanabe M, Onda A, Komatsu T, Sakai K, Umehara T, Mitsumura H, Iguchi Y. Cerebral Small Vessel Disease is Associated with Prehospital Delay in Acute Ischemic Stroke. J Atheroscler Thromb. 2024; 32(2): 198209.
  36. Okumura M, Sato T, Takahashi J, Kokubu T, Nakada R, Kitagawa T, Tanabe M, Takatsu H, Onda A, Komatsu T, Sakuta K, Sakai K, Umehara T, Mitsumura H, Iguchi Y. Small ischemic lesions accompanying intracerebral hemorrhage: The underlying influence of old lacunes and polyunsaturated fatty acids. Nutr, Metab Cardiovasc Dis. 2024; 34(5): 1157-65.
  37. Okumura M, Sato T, Ishikawa T, Kokubu T, Takahashi J, Kitagawa T, Nakada R, Takatsu H, Onda A, Komatsu T, Sakuta K, Sakai K, Umehara T, Mitsumura H, Matsushima M, Iguchi Y. Deep and infratentorial cerebral microbleeds are related to wake-up stroke by large-artery atherosclerosis and cardioembolism. J Neurol Sci. 2024; 456: 122813.
  38. Okumura M, Mukai Y, Saika R, Takahashi Y. Association of severe hyposmia and frontal lobe dysfunction in patients with Parkinson’s disease. J Neurol Sci. 2024; 465: 123205.
  39. Sato T, Okumura M, Ishikawa T, Sakuta K, Takahashi J, Tanabe M, Onda A, Komatsu T, Sakai K, Umehara T, Mitsumura H, Iguchi Y. Relationship between ω3 and ω6 polyunsaturated fatty acids and atrial fibrillation in acute ischemic stroke. Clin Nutr. 2024; 43(6): 1643-51.
  40. Ishikawa T, Sato T, Okumura M, Kokubu T, Takahashi J, Kitagawa T, Tanabe M, Takatsu H, Onda A, Komatsu T, Sakuta K, Sakai K, Umehara T, Mitsumura H, Iguchi Y. Bathing-Related Ischemic Stroke: Association between Stroke Subtype and Cerebral Small Vessel Disease. J Atheroscler Thromb. 2024; 31(12): 1692-702.

Ⅱ. 総説

  1. Kakuda W, Nakajima M, Oki K, Koyama T, Oyama N, Koga M, Hayase M, Ohta T, Iguchi Y, Fujimoto S, Omori T, Matsumoto K, Hashimoto Y, Itabashi R, Niimi M, Ashiga H, Tajima F, Ogasawara K. Evidence and Recommendations for Acute Stroke Rehabilitation from the Japan Stroke Society: Abridged Secondary Publication of the Japanese-language Version. Prog Rehabilitation Med. 2024; 9(0): 20240015.
  2. 谷口洋．1枚の写真．吸気時の喘鳴の原因は何でしょうか？　嚥下医学2024; 13(2): 157-159.
  3. 三村秀毅．脳卒中と心臓病の合併：スクリーニングと治療への配慮．特集 II ブレインハートチーム．脳神経内科．2025; 102(2): 237-42.
  4. 仙石錬平．特集　レビー小体病の非運動症状を知ろう　レビー小体病の病理学的進展と非運動症状．日本医師会雑誌2025; 153(12): 1276-80.
  5. 仙石錬平．【患者さんからよく尋ねられる内科診療の Question】第9章神経［62歳男性，Parkinson 病］ 3年前から Parkinson 病と言われて内服が始まりました．でもなるべく薬を飲みたくないのです（Q&A）．内科2024; 133(4): 914-7.
  6. 仙石錬平．DLB と PDD は同じスペクトラム上にあるのか　病理学的な視点から．神経治療学2024; 41(4): 548-50.
  7. 仙石錬平．【Lewy 小体病に見られる Alzheimer 型認知症】神経病理学的にみる．Dementia Japan 2024; 39(1): 36-40.
  8. 仙石錬平．難病医療　神経変性疾患・病態解明の最前線．難病と在宅ケア2024; 30(9): 44-7.
  9. 仙石錬平．【睡眠と自律神経 update】Lewy 小体病の病理と睡眠障害．脳神経内科2024; 101(5): 618-23.
  10. 仙石錬平．PSP と CBD を分けることは有用　No の立場から．MDSJ Letters 2024; 17(1): 4-6.
  11. 作田健一，井口保之．【症状性・器質性精神障害診療ガイド―精神症状を引き起こす身体疾患, 物質・医薬品―（2024年版）】（第2章）中枢神経系疾患　脳血管障害　高血圧性脳症（RPLS/PRES を含む）．精神科治療学（0912-1862）39巻増刊 Page112-113（2024.10）．
  12. 小松鉄平，井口保之．アテローム血栓性脳梗塞．脳画像で読み解く脳神経疾患．BRAIN NURSING．大阪：メディカ出版，2024．p.32-36.
  13. 茂木晴彦，北川賢，中原仁．【治る, 予防できる脳神経疾患―現状と将来】多発性硬化症と視神経脊髄炎関連疾患の治療　現状と将来（解説）．医学のあゆみ．2024; 289(12): 885-891.

Ⅲ. 症例報告

  1. 須貝純，大谷圭，仙石錬平，卯津羅雅彦．幻視や幻聴，姿勢保持障害など精神病症状を主訴に来院した慢性硬膜下血腫の1例．日本救急医学雑誌2024; 35(9): 318-22.
  2. Tokuhisa T, Hayashi T, Omoto S, Kozaki A, Inoue T, Nakano T. Dysthyroid Optic Neuropathy Complicated by Neuromyelitis Optica Spectrum Disorder: A Case Report. Case Rep Ophthalmol 2024; 15(1): 621-7.
  3. Komatsu T, Motegi H, Nakayama Y, Matsuno H, Mitsumura H, Iguchi Y. Sustained Minimal Manifestations With Extended Interval Dosing of Efgartigimod in Seronegative Myasthenia Gravis: Case Report. Muscle Nerve. 2025. doi:10.1002/mus.28388. Online ahead of print.
  4. 小山睦美，林孝彰，福永直子，飯田由佳，徳久照朗，高津宏樹，大本周作，丹野有道，中野匡．未治療 2型糖尿病に発症した両眼性抗アクアポリン4抗体陽性視神経炎にサトラリズマブを導入した1例．臨床眼科2024; 78(3): 327-35.
  5. 藤巻美萌，北川友通，仙石錬平．メコバラミン内服中にビタミン B12上昇不良であったことを契機に亜急性連合性脊髄変性症と診断した1例．日内会誌2025; 114(3): 515-22.
  6. Ozawa M, Shibata K, Toyoda K, Kitagawa T, Ikeda M, Sengoku R. Serial diffusion-weighted, voxel-based morphometry MRI, and 123I-IMP SPECT in V180I genetic Creutzfeldt–Jakob disease before symptom onset. Medical Reports. 2024; 6: 100072.
  7. 佐藤健朗，佐竹真理，飯塚公己，三森雅広，梅原淳，竹内千仙，井口保之．弁粘液腫状変性を伴うMarfan 症候群に一過性黒内障を発症した1例．臨床神経学．2024; 64(10): 719-24.
  8. 神津実咲，佐藤健朗，三森雅広，奥村元博，梅原淳，井口保之．垂直方向に長大な病変を呈し発症早期に中枢性呼吸障害を伴った延髄外側梗塞の1例．脳卒中．2024; 46(4): 326-31.
  9. 三森雅広，小松鉄平，深澤寧，幕昂大，荒井晶聖，稲生綺与子，大野亜里沙，岡本亜里紗，塩原望実，寺本昌史，井口保之．発症2ヶ月で無動無言に至った孤発性クロイツフェルト・ヤコプ病の1剖検例（第779回 CPC 症例）．慈大誌; 139(5): 119-24.
  10. Matsumura S, Sato T, Matsushima S, Kokubu T, Umehara T, Komatsu T, Sakai K, Mitsumura H, Iguchi Y. Retropharyngeal abscess due to Fusobacterium necrophorum complicated by progressive internal carotid artery stenosis and multiple cranial nerve palsies. Head Neck. 2024; 46(5): E57-60.
  11. Okumura M, Sato T, Masui M, Kokubu T, Umehara T, Okamoto T, Iguchi Y. Magnetic Resonance Imaging/cerebrospinal Fluid-negative Myelitis Following COVID-19 with a Dramatic Response to Early Aggressive Immunosuppressive Therapy. Intern Med. 2024; 63(15): 2199-201.
  12. Okumura M, Mukai Y, Tanimura J, Takahashi Y. Jaw-opening dystonia in Parkinson’s disease improved by foslevodopa-foscarbidopa continuous subcutaneous infusion: a case report. Neurol Sci. 2024; 45(12): 5939-5941.
  13. Okumura M, Sekiguchi K, Okamoto T, Saika R, Maki H, Sato W, Sato N, Yamamura T, Takahashi Y. ʻGrasshopper sign’: the novel imaging of post-COVID-19 myelopathy with delayed longitudinal white matter abnormalities. BMJ Neurol Open. 2024; 6(1): e000730.
  14. Nomoto J, Takatsu H, Yoshida K, Matsuzawa H, Omoto S. Effectiveness of Intravenous Cyclophosphamide in a Patient with Anti-amphiphysin Autoimmunity Presenting With Bulbar Palsy and Cerebellar Ataxia: A Case Report. Curreus. 2024 Jul 25; 16(7): e65350.

Ⅳ. 著書

  1. 井口保之．血管性うつ病．高木誠他．今日の治療指診．東京：医学書院，2024. p.940-1.
  2. 仙石錬平（狛江市健康づくり推進協議会委員協力者）．健康こまえ21（第3次）・食育推進計画（第3次）・いのち支える自殺対策計画（第2次）―ウェルこまヘルスプラン―　2025年3月．
  3. 小松鉄平，井口保之．静注血栓溶解療法．脳梗塞診療読本．東京：中外医学社，2024．p.83-94．
  4. 小松鉄平，井口保之．一過性脳虚血発作（TIA）．SCU グリーンノート改訂第2版．東京：中外医学社，2025．p.193-198．
  5. 小澤正和，井口保之．コラム：神経変性疾患．小澤一史編集代表．Crosslink basic リハビリテーションテキスト解剖学．東京．メジカルビュー社，2025．p.208．
  6. 三森雅広．Topic 3　神経軸索スフェロイド形成を伴う遺伝性びまん性白質脳症（HDLS）．山村隆（監修），岡本智子（編集），佐藤和貴郎（編集）．多発性硬化症・視神経脊髄炎診療のすべて．東京：診断と治療社，2025年．p.65-67．

Ⅴ.研究費

  1. 仙石錬平．認知症スクリーニング AI モデルの開発．AMED・認知症研究開発事業　東京大学亀山祐美班．2024年度．
  2. 小松鉄平．間葉系幹細胞を含有した X 線視認性ファイバーによる脳梗塞カテーテル治療．科学研究費助成事業若手研究．2022年度～2025年度．
  3. 小松鉄平．臓器虚血モデルにおける LIPUS 治療と再生医療の有効性と安全性．東京慈恵会医科大学「大学間共同プロジェクト研究費」．2024年度．
  4. 小松鉄平．抗フィブリン抗体と変異ウロキナーゼの融合体による急性期脳梗塞に対する新規血栓溶解剤の開発．公益財団法人 MSD 生命科学財団研究助成2023生活習慣病領域（循環器分野）若手研究者．2024年1月～2025年12月．
  5. 小松鉄平，井口保之．視神経脊髄炎スペクトラム障害患者におけるレジストリ研究．中外製薬株式会社．2024年度．
  6. 小松鉄平，横山昌幸．血栓溶解剤の新地平：急性期及び慢性期脳神経疾患への新規血栓溶解剤の適用．科学研究費助成事業基盤研究 ．2024年度～2026年度．
  7. 松野博優．近位筋優位遺伝性運動感覚ニューロパチーの患者由来 iPS 細胞を用いた病態解明．科学研究費助成事業・研究活動スタート支援．2021年度～2024年度．
  8. 恩田亜沙子．TDP-43変異導入ヒト iPS 細胞由来ニューロンを用いた筋萎縮性側索硬化症の病態解明．研究活動スタート支援．2022～2024年度．

Ⅵ. 特許

  1. 松村保広，花岡慎悟，小松鉄平，横山昌幸，太田裕貴．フィブリンに結合する抗体および当該抗体を含むフィブリン溶解性タンパク質および当該タンパク質を含む医薬製剤．PCT/JP2025/005634，2025年．

Ⅶ. 賞

  1. 白石朋敬．令和6年度　日本学術振興会　海外特別研究員．

Ⅷ．その他

  1. Renpei Sengoku. (Symposium) Neuropathologic features of cognitive decline in Lewy Body Dementia. The Autumn Symposium of The Korean Movement Disorder Society, Gyeongju, Oct.
  2. Renpei Sengoku. (Symposium) Tau pathology in Lewy Body Disease: A Neuropathologic Perspective. The Autumn Symposium of The Korean Movement Disorder Society, Gyeongju, Oct.
  3. Umehara T, Nakayama Y, Nomoto J, Mimori M, Sato T, Onda A, Matsuno H, Komatsu T, Sakai K, Mitsumura H, Iguchi Y. Peripheral immune profile in de novo Lewy body diseases. 65th Annual Meeting of the Japanese Society of Neurology and 19th Asian Oceanian Congress of Neurology (AOCN2024). Tokyo, May.
  4. Sakuta K, Ghovvati M, Imahori T, Guo L, Tateshima S, Kaneko N. Difference in Device Slacks in Combined Technique Causes Clot Segmentation. 17th Congress of World Federation of Interventional and Therapeutic Neuroradiology. New York, Oct
  5. Sakuta K, Ghovvati M, Guo L, Tateshima S, Kaneko N. Impact of tissue Plasminogen Activator on thrombus weight and composition. International Stroke Conference. Los Angeles, Feb.
  6. Nakada R, Sakuta K, Okumura M, Kida H, Kitagawa T, Sato T, Takatsu H, Miyagawa S, Komatsu T, Sakai K, Mitsumura H, Yaguchi H, Iguchi Y. The Enigmatic Role of Collateral Circulation: Penumbra Survival in Large Vessel Occlusion (ePoster). Society of Neurointerventional Surgery 21st Meeting. 2024 July.
  7. Motegi H, Sekiguchi K, Kitagawa S, Ueda R, Kufukihara K, Hase M, Fujiwara H, Jinzaki M, Iguchi Y, Nakahara J. Associations between glymphatic system changes and clinical disability in multiple sclerosis and neuromyelitis optica spectrum disorder. 40th ECTRIMS, Copenhagen, Sept.［ Multiple Sclerosis Journal 2024; 30 (Issue 3, Suppl)］
  8. Kida H, Sakai K, Komatsu T, Okumura M, Nakada R, Kitagawa T, Takatsu H, Sakuta K, Mitsumura H, Iguchi Y. Lupus Anticoagulant Is Associated With Acute Recurrence in Cardiogenic Embolic Stroke in Older Patients. International stroke conference 2025. Los Angeles, Feb, 2025.［ Stroke. 56. suppl1.］
  9. （Poster）Okumura M, Sato T, Tsujimoto Y, Yamashiro K, Watanabe Y, Kida H, Kitagawa T, Nakada R, Takatsu H, Komatsu T, Sakuta K, Sakai K, Mitsumura H, Nishimura R, Iguchi Y. Primary Aldosteronism in Acute Ischemic Stroke: Association With Small Vessel Disease. International Stroke Conference 2025, California, USA, Feb.
  10. Nakayama Y, Kida H, Maku T, Nakada R, Kitagawa T, Takatsu H, Komatsu T, Sakuta K, Sakai K, Mitsumura H, Iguchi Y. Multimodal MRI sequences are vital for the diagnosis of Vertebrobasilar Artery Dissection. International Stroke Conference 2025. Los Angeles, February.
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東京慈恵会医科大学 内科学講座 脳神経内科

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